Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): implications for the origin and emergence of Middle East respiratory syndrome coronavirus
Identifieur interne : 002058 ( Main/Exploration ); précédent : 002057; suivant : 002059Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): implications for the origin and emergence of Middle East respiratory syndrome coronavirus
Auteurs : Jie Cui ; John-Sebastian Eden ; Edward C. Holmes ; Lin-Fa WangSource :
- Virology Journal [ 1743-422X ] ; 2013.
Descripteurs français
- KwdFr :
- Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Attachement viral, Cartographie d'interactions entre protéines, Chiroptera, Coronavirus (physiologie), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Liaison aux protéines, Phylogénie, Protéines de l'enveloppe virale (métabolisme), Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Sélection génétique, Évolution moléculaire.
- MESH :
- génétique : Dipeptidyl peptidase 4, Récepteurs viraux.
- métabolisme : Dipeptidyl peptidase 4, Protéines de l'enveloppe virale, Récepteurs viraux.
- physiologie : Coronavirus.
- Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Attachement viral, Cartographie d'interactions entre protéines, Chiroptera, Liaison aux protéines, Phylogénie, Sélection génétique, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Chiroptera, Cluster Analysis, Coronavirus (physiology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Evolution, Molecular, Phylogeny, Protein Binding, Protein Interaction Mapping, Receptors, Virus (genetics), Receptors, Virus (metabolism), Selection, Genetic, Sequence Analysis, DNA, Viral Envelope Proteins (metabolism), Virus Attachment.
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, Receptors, Virus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Receptors, Virus, Viral Envelope Proteins.
- physiology : Coronavirus.
- Animals, Chiroptera, Cluster Analysis, Evolution, Molecular, Phylogeny, Protein Binding, Protein Interaction Mapping, Selection, Genetic, Sequence Analysis, DNA, Virus Attachment.
Abstract
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) that first appeared in Saudi Arabia during the summer of 2012 has to date (20th September 2013) caused 58 human deaths. MERS-CoV utilizes the dipeptidyl peptidase 4 (DPP4) host cell receptor, and analysis of the long-term interaction between virus and receptor provides key information on the evolutionary events that lead to the viral emergence.
We show that bat
Our study suggests that the evolutionary lineage leading to MERS-CoV may have circulated in bats for a substantial time period.
The online version of this article (doi:10.1186/1743-422X-10-304) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1743-422X-10-304
PubMed: 24107353
PubMed Central: 3852826
Affiliations:
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Le document en format XML
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<term>Dipeptidyl Peptidase 4 (genetics)</term>
<term>Dipeptidyl Peptidase 4 (metabolism)</term>
<term>Evolution, Molecular</term>
<term>Phylogeny</term>
<term>Protein Binding</term>
<term>Protein Interaction Mapping</term>
<term>Receptors, Virus (genetics)</term>
<term>Receptors, Virus (metabolism)</term>
<term>Selection, Genetic</term>
<term>Sequence Analysis, DNA</term>
<term>Viral Envelope Proteins (metabolism)</term>
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<term>Analyse de séquence d'ADN</term>
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<term>Attachement viral</term>
<term>Cartographie d'interactions entre protéines</term>
<term>Chiroptera</term>
<term>Coronavirus (physiologie)</term>
<term>Dipeptidyl peptidase 4 (génétique)</term>
<term>Dipeptidyl peptidase 4 (métabolisme)</term>
<term>Liaison aux protéines</term>
<term>Phylogénie</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
<term>Récepteurs viraux (génétique)</term>
<term>Récepteurs viraux (métabolisme)</term>
<term>Sélection génétique</term>
<term>Évolution moléculaire</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term>
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<term>Récepteurs viraux</term>
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<term>Récepteurs viraux</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) that first appeared in Saudi Arabia during the summer of 2012 has to date (20th September 2013) caused 58 human deaths. MERS-CoV utilizes the dipeptidyl peptidase 4 (DPP4) host cell receptor, and analysis of the long-term interaction between virus and receptor provides key information on the evolutionary events that lead to the viral emergence.</p>
</sec>
<sec><title>Findings</title>
<p>We show that bat <italic>DPP4</italic>
genes have been subject to significant adaptive evolution, suggestive of a long-term arms-race between bats and MERS related CoVs. In particular, we identify three positively selected residues in DPP4 that directly interact with the viral surface glycoprotein.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our study suggests that the evolutionary lineage leading to MERS-CoV may have circulated in bats for a substantial time period.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1743-422X-10-304) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<tree><noCountry><name sortKey="Cui, Jie" sort="Cui, Jie" uniqKey="Cui J" first="Jie" last="Cui">Jie Cui</name>
<name sortKey="Eden, John Sebastian" sort="Eden, John Sebastian" uniqKey="Eden J" first="John-Sebastian" last="Eden">John-Sebastian Eden</name>
<name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name>
<name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name>
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